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Department of Health Services

Public Health Regional Laboratory

Syphilis – VDRL

This is a non-treponemal screening test for syphilis. False positive results may occur due to systemic lupus erythematosus, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy. Monitoring of RPR is helpful in assessing effectiveness of therapy.

Portal Ordering Code

Syphilis-VDRL

CPT Code(s)

86592

Fee Schedule

Storage and Transport Criteria
Specimen Storage Specimen Transport
Acceptable Specimens
Minimum Volume
Frozen Range
-70°C - 0°C
Refrigerated Range
0.1°C - 8°C
Room Temperature Range
8.1°C - 30°C
Stability at
4°C - 25°C
CSF 0.5 mL Acceptable at -20°C indefinitely Acceptable up to 5 days Reject 8 hours
Serum 1 mL Acceptable at -20°C indefinitely Acceptable up to 5 days Reject 8 hours
Includes
  • CSF - If VDRL screen is Reactive, then VDRL Titer testing will be performed at an additional charge (CPT Code: 86593).
  • Serum - If VDRL screen is Reactive, then VDRL Titer and TPPA testing will be performed at an additional charge (CPT Code(s): 86593, 86780).
Methodology

Flocculation

Assay Category

FDA Approved

Reference Range

See laboratory report

Alternative Names
  • Syphilis Serology Screen
  • PR(Dx) rfl Ttr/T.pallidum
  • Blood Premarital RPR
  • Automated Reagin Test
  • ART
  • Rapid Plasma Reagin
Preferred Specimen(s)
  • CSF
  • Serum
Alternative Specimen(s)

N/A

Minimum Volume
  • CSF - 0.5 mL
  • Serum - 1 mL
Special Instructions

CSF - Confirmatory TPPA cannot be performed on CSF.

Reject Criteria
  • Inadequately labeled specimens
  • Leaking specimens
  • QNS (quantities not sufficient)
  • Specimens not meeting the Storage & Transport criteria upon receipt at laboratory
Setup Schedule

Testing done once a week.

Turn around time (TAT)

7 business days from arrival at the lab